DUBLIN–(BUSINESS WIRE)–The “Epilepsy – Pipeline Insight, 2021” clinical trials has been added to ResearchAndMarkets.com’s offering.
This Epilepsy – Pipeline Insight, 2021 provides comprehensive insights about 70+ companies and 70+ pipeline drugs in Epilepsy pipeline landscape.
It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Report Highlights
The companies and academics are working to assess challenges and seek opportunities that could influence Epilepsy R&D. The therapies under development are focused on novel approaches to treat/improve Epilepsy.
Epilepsy Emerging Drugs Chapters
This segment of the Epilepsy report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Epilepsy Emerging Drugs
GWP42003-P: GW Research
Epidiolex (formerly, GWP42003-P) is an oral cannabidiol solution that GW Pharmaceuticals developed. The U.S. Food and Drug Administration (FDA) approved it to treat seizures in patients with Dravet syndrome and Lennox-Gastaut syndrome age 1 and older. Epidiolex is a plant-derived cannabidiol, a non-psychoactive marijuana extract. It is currently being investigated in Phase III clinical trial to treat Epilepsy.
Ganaxolone: Marinus Pharmaceuticals
Ganaxolone is a GABAA receptor modulator that acts by regulating brain activity is being evaluated in Phase III stage of development. This process can include inhibiting the abnormal electrical discharges that cause seizures and status epilepticus or restoring balance in disrupted neuronal activity in other CNS disorders.
Because ganaxolone modulates both synaptic and extrasynaptic GABAA receptors and is unique relative to other approved antiepileptic drugs, we believe it has the potential to treat seizures resistant to other available medications. These binding sites, including the extrasynaptic GABAA receptor, may also be important in treating status epilepticus and other brain disorders.
XEN496: Xenon Pharmaceuticals
XEN496, a Kv7 potassium channel modulator that is a proprietary pediatric formulation of the active ingredient ezogabine being developed for the treatment of KCNQ2 developmental and epileptic encephalopathy (KCNQ2-DEE). With the U.S. Food and Drug Administration (FDA) having completed its review of the clinical trial protocol, Xenon is on track to initiate the XEN496 Phase 3 clinical trial in pediatric patients with KCNQ2-DEE.
In addition, Xenon has received a positive opinion from the Committee for Orphan Medicinal Products (COMP) of the European Medicines Agency (EMA), which recommends the granting of an orphan medicinal product designation for XEN496 for the treatment of KCNQ2-DEE. This European designation is in addition to the FDA granting Fast Track designation for XEN496 for the treatment of seizures associated with KCNQ2-DEE as well as Orphan Drug Designation (ODD) for the treatment of KCNQ2-DEE.
CVL-865: Cereval therapeutics
The positive allosteric modulator (PAM) of GABAA channels, CVL-865 has been shown in a phase II trial to have pronounced anticonvulsant activity in patients with photosensitive epilepsy, with efficacy similar to lorazepam. CVL-865 acts at GABAA channels with a2, a3, and a5 subunits, known to have anticonvulsant (a2 only), analgesic, anxiolytic, and muscle-relaxing properties from GABAergic PAMs. It is hoped that CVL-865, by selectively modulating a2, a3, and a5 will enable higher receptor occupancy than can be achieved with non-selective benzodiazepines and achieve seizure suppression with greater tolerability owing to fewer sedative or cognitive effects.
ES-481: ES Therapeutics
ES-481 is being developed by ES Therapeutics for the treatment of Epilepsy. ES therapeutics is conducting Phase IIA single-arm exploratory clinical study in up to 12 adult subjects aged 18 and older with primary glioma, IDH1 mutation, and uncontrolled focal-onset seizure activity to determine the potential efficacy, safety and pharmacokinetics of ES-481 as adjunctive therapy in glioma-associated epilepsy and to assess for potential anti-tumorigenic effects.
Major Players in Epilepsy
There are approx. 70+ key companies which are developing the therapies for Epilepsy. The companies which have their Epilepsy drug candidates in the most advanced stage, i.e. Phase III include, GW Research.
Key Questions Answered
- How many companies are developing Epilepsy drugs?
- How many Epilepsy drugs are developed by each company?
- How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Epilepsy?
- What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Epilepsy therapeutics?
- What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
- What are the clinical studies going on for Epilepsy and their status?
- What are the key designations that have been granted to the emerging drugs?
Key Topics Covered:
Introduction
Executive Summary
Epilepsy: Overview
- Causes
- Mechanism of Action
- Signs and Symptoms
- Diagnosis
- Disease Management
Pipeline Therapeutics
- Comparative Analysis
Therapeutic Assessment
- Assessment by Product Type
- Assessment by Stage and Product Type
- Assessment by Route of Administration
- Assessment by Stage and Route of Administration
- Assessment by Molecule Type
- Assessment by Stage and Molecule Type
Late Stage Products (Phase III)
- Comparative Analysis
GWP42003-P: GW Research
- Product Description
- Research and Development
- Product Development Activities
Mid Stage Products (Phase II)
- Comparative Analysis
CVL-865: Cereval therapeutics
- Product Description
- Research and Development
- Product Development Activities
Early stage products (Phase I)
- Comparative Analysis
OPC-214870: Otsuka Pharmaceutical
- Product Description
- Research and Development
- Product Development Activities
Inactive Products
- Comparative Analysis
Epilepsy Key Companies
Epilepsy Key Products
Epilepsy-Unmet Needs
Epilepsy Market Drivers and Barriers
Epilepsy Future Perspectives and Conclusion
Epilepsy Analyst Views
Epilepsy Key Companies
- Aadi, LLC
- Abraxis Bioscience
- Adamas Pharmaceuticals
- Alexza Pharmaceuticals
- Arvelle Therapeutics
- AXONIS Therapeutics
- Bial – Portela C S.A
- Bio-Pharm Solutions
- Biogen
- Cerevel Therapeutics
- Corlieve Therapeutics
- Eisai Inc.
- Epygenix Therapeutics
- ES therapeutics
- GW Pharmaceuticals
- Idorsia Pharmaceuticals
- Janssen Research & Development
- Jazz Pharmaceuticals
- Marinus Pharmaceuticals
- NeuCyte
- Neurocrine Biosciences
- NobelPharma
- OB Pharmaceuticals
- Otsuka Pharmaceutical
- Ovid Therapeutics
- Pear Therapeutics
- Pfizer
- PhytoTech Therapeutics
- Praxis Precision medicines
- PTC therapeutics
- Q-state Biosciences
- SK Biopharmaceuticals
- SK Life Science, Inc.
- Stoke Therapeutics
- Takeda
- Tevard Biosciences
- Tilray
- UCB Biopharma
- Xenon Pharmaceuticals
- Zogenix International
For more information about this clinical trials report visit https://www.researchandmarkets.com/r/6iou1c
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